Sunday, October 04, 2015

A Cheap, Safe Anti-Cancer Therapy Effective Against the Majority of Human Cancers

DISCLAIMER: I am not a medical doctor or a pharmacist. This is not a medical prescription. I am a former molecular biologist with prostate cancer and a variation of this cocktail is killing my prostate cancer. I am not endorsing any company or product either. I am only telling you from my experience and knowledge what will work. Do not stop any cancer treatment you are currently on. What you may want to do is supplement it with this one.

This should be an effective over-the-counter combinatorial chemotherapy regime for the majority of cancers. There are caveats. I will list the ingredients and dosages first:

Drug or Supplement                                       Daily Dosage
Aspirin                                                                2 350mg pills
Resveratrol                                                        2 100mg pills
Quercetin                                                           2 650mg pills
Sulforaphane                                                     4 400mcg pills
Nicotinamide riboside                                       1 100mg pill
Sodium dichloroacetate                                    2 500mg
Glutamine (neuropathy)                                  30 500mg pills
Thiamine (neuropathy)                                      1 100mg pill

 
Additional Supplements or Drugs with the above combination:

Glioma
imipramine                                                        (unknown currently)
ticlopidine                                                          (unknown currently)

Pancreatic cancer 
L-methionine                                                     6 500mg pills

Take 500mg of the DCA twice per day. Mix the powder with water and drink it. Except for sodium dichloroaceate and aspirin, the effective optimum dosage of the other ingredients is unknown. However, after 1-2 weeks, your body should be saturated anyway.  You should discontinue taking the sodium dichloroacetate (DCA) after 2.5 months (unless you supplement it with the glutamine) for a period of 2-4 weeks* because the sodium dichloroacetate induces peripheral neuropathy.

For cancer prevention, take the first 4-5 ingredients daily with the mitoQ supplement. Your mileage may vary.

Rational

The reasoning is complex due to molecular biological reasons, but the research is very sound. The short answer to why this works is manifold:

1. The DCA inhibits aerobic glycolysis to an extent which is the energy supply of the cancer cells thereby starving them. It turns on the mitochondria which sense something is amiss and signal the cell to commit suicide. Sulforaphane should enhance this killing effect by inhibiting HIF-1-alpha which turns on aerobic glycolysis and turns off the mitochondria.
2. Quercetin and resveratrol make the cells think they are starving and promote autophagy. This mimics caloric restriction which has been proven to extend lifespan in many organisms from yeast to mammals including primates.
3. Aspirin is known to reduce the incidence of colorectal cancers possibly by COX2 inhibition or other mechanisms.
4. Quercetin and sulforaphane together have been shown to have an enhanced ability to kill pancreatic cancer stem cells in vitro.
5. Aspirin and resveratrol together have been shown to have an enhanced  ability to kill abnormal tetraploid cells, especially abnormal cells derived from the gut. For cancers to spread, they usually have to have multiple chromosomes, a state called aneuploidy, as one of the conditions. Once cancer cells spread, the condition is usually terminal.

The sodium dichloroacetate is the main actor in killing the cancer. It can kill most cancers by itself alone. However, the quercetin and sulforaphane will likely enhance its effectiveness many times over. The aspirin and resveratrol will kill any cells that have multiple chromosomes thereby making it less likely the cancer will spread if it is localized. The latter four compounds will likely kill most cancer cells on their own, or at least slow their growth to a significant extent through induction of autophagy. What we are doing here is very simple. We are killing cancer cells by hitting molecular targets at multiple sites. If we just use one drug, like sodium dichloroacetate, we will be selecting for survivors. We are hitting cancer cells in up to five different places, so the likelihood of any survivors, is effectively zero. This is why chemotherapy consists of two or more drugs. Doctors learned the hard way that trying to kill cancer with one drug is usually futile with fatal results for their patients.

Caveats:
1. There has been no clinical trials of this regime and there never will be in the United States or any other advanced country. So, I only have the medical literature and my own experience to go on.
2. With certain advanced cancers like pancreatic cancer, the chances of this regime being completely effective are unknown. By the time one is diagnosed with pancreatic cancer, the person is at a terminal advanced stage. The problem with pancreatic cancer is that the cachexia (wasting) weakens them to the point that traditional chemotherapy is ineffective. The cachexia is due to cancer-induced methionine starvation. That said, the latest medical research suggests that quercetin and sulforaphane together effectively kill pancreatic cancer stem cells.

* This is a guesstimate. I have mild DCA-induced neuropathy and I just went off DCA after three months use. It is supposed to be reversible. But, this neuropathy is not a bad side effect compared to the effects of traditional chemotherapy which are pretty brutal.

P.S. My prostate cancer is localized and low risk. I am under active surveillance which basically means watch and wait. If it got worse, I would probably have to undergo a radical prostatectomy. My urologist would not prescribe DCA, so I thought I had nothing to lose if I self-medicated. If it did not work, I lost nothing. If it did work, I would have peace of mind and an intact prostate and reproductive system. I had a PSA level of 6.4 in May. I underwent a biopsy June 4th. I was diagnosed with prostate cancer a week later. I started supplementing the aspirin, resveratrol, and quercetin with DCA around the end of June. I added nicotinamide riboside in July. On September 17th, my PSA level was 2.5. I have been taking resveratrol and aspirin daily for about 2.5-3 years now, before I was diagnosed with prostate cancer. It did not stop the cancer on its own. Additionally, I started taking quercetin the latter half of March 2015 for cardiovascular health. I did not know about its anticancer effects until yesterday, but I knew it promoted apoptosis of senescent endothelial and bone marrow stem cells. I plan to add sulforaphane to my personal regime shortly.


Monday, September 14, 2015

Changing the Kali Linux 2.0 Default Password

I could not find this documented. There is a script in /lib/live/config called 0031-root-password. It invokes the usermod command:

usermod -p ‘X014elvznJq7E’ root

which needs to be commented out and the filesystem compressed using mksquashfs. There is likely another way as well, but I have not searched for it.

Sunday, July 13, 2014

No KDE Display Manager (kdm) on RHEL7 and clones

Red Hat considers kdm to be dead. If you are trying to build a minimal installation, you'll have to substitute ldm (light display manager) for gdm. Go to rpmfind.net or one of the other repositories and download the following files:

desktop-backgrounds-compat-20.0.0-1.fc20.noarch.rpm
heisenbug-backgrounds-base-20.0.0-1.fc20.noarch.rpm
lightdm-1.8.8-1.fc20.x86_64.rpm
lightdm-gobject-1.8.8-1.fc20.x86_64.rpm
lightdm-gtk-1.6.1-3.fc20.x86_64.rpm

Then, run the following commands:
rpm -i --force desktop-backgrounds-compat*.rpm heisenbug*.rpm
yum localinstall lightdm-1.8.8*.rpm lightdm-gobject-1.8.8-1*.rpm lightdm-gtk-1.6.1-3*.rpm
systemctl disable gdm.service
systemctl enable lightdm.service
reboot

If you miss the default background, you can do this:

rpm -i --force centos-logos-70.0.6-1.el7.rpm

Monday, May 05, 2014

Fixing and Compiling OpenSSL on Ubuntu 14.04

I have been reading OpenSSL Valhalla Rampage almost daily since it was started. I began to wonder if I could incorporate some of their fixes into OpenSSL. I also wondered just how buggy OpenSSL really was. I went to openssl.org and downloaded the latest tarball. I unpacked it. Since I had clang installed and it has a static source code analyzer, I changed directories into the unpacked openssl-1.0.1g directory and ran the following command:

scan-build -o /home/jbmoore/openssl-bugs make -j4

The o option tells scan-build where to send its output. Upon completion, you are given a command to run:

scan-view /home/jbmoore/openssl-bugs/2014-05-04-181351-14781-1

which displays the results in a browser.


I then modified the source files based on code snippets from OpenSSL Valhalla Rampage. I reran the scanner to see if some of the bugs disappeared and they had. When I tried to compile my changes with make test and make install, I got a linker error:

../libcrypto.a(v3_alt.o):v3_alt.c:(.text+0x2478): more undefined references to `strlcpy' follow collect2: error: ld returned 1 exit status.

I tried various things, but in the end, I had to be missing a library. Since Ubuntu 14.04 does not have ia32-libs, I went and downloaded the package ia32-libs-multiarch_20090808ubuntu36_i386.deb from the Precise repository and installed it with dpkg:

      dpkg -i ia32-libs-multiarch_20090808ubuntu36_i386.deb

which will fail. That result is fine because I knew it would fail a dependency check. I then ran apt-get -f install which installed all dependencies. There were a lot, 30-40 or more 32-bit libraries installed. By the time I had done this, I had downloaded the original Ubuntu source package, openssl-1.0.1f and modified it. So, the quick and dirty way is:

1. install ia32-libs-multiarch_20090808ubuntu36_i386.deb, then
2. apt-get source openssl, followed by
3. apt-get build-dep openssl,
4. modify the openssl source code using hints from the libressl project, and
5. apt-get -b source openssl.

You can run scan-build before and after you compile the debian packages to see how many bugs you've eliminated. This bug fix just shifted the segmentation fault from openssl to a glibc library function which tells me that glibc probably needs fixing as well. The openssl crash is triggered by the following code:

sudo echo ZW5jb2RlIG1lCg================================================================== | openssl enc -d -base64

This bug has been known for three years, and until now, it was not fixed. Kudos to the openBSD developers. I wish I knew a more elegant way to determine which library is missing, but I am still ignorant at this time. This framework will allow you to at least follow along with the libressl developers and give you an idea how to find and fix bugs in Linux programs. I should add that to do it properly, you should be making changes using either subversion or git. I just was curious about how difficult it would be. It is not really that hard provided you have all the 32-bit libraries you need to compile the openssl and libssl packages.

Tuesday, March 04, 2014

Economists Were Told Five Years Before the GFC That It Would Happen

When you read in a paper or hear someone state that nobody knew the financial world was going to explode in 2008, they are either misinformed or a liar. William White, a central banker warned them for over five years that there was trouble brewing and that it should be stopped. They refused to believe him and replied that he didn't have any model to back up his analysis.


The painting is not the object of the painting. An economic model is not the thing being modeled.  It is at best a very good approximation, and at worst, a terrible fantasy. Models have to be proven by evidence. Evidence is used to explain models as well. Evidence can exist without a model or narrative. But, models do not exist without evidence, except in economics and other forms of pseudo science. William White says that central bankers are making it up as they go and they can't even agree on what needs to be done. The funny thing is that none of them have lost their salaries or careers for ignoring clear warnings of imminent failure of their governance and policies. They've all failed upwards. May be we should make them all swear to "Do no harm" and put claw back clauses in their employment contracts in case they fail at their jobs. Of course, that would work for politicians and investment bankers as well.
 

Sunday, December 29, 2013

Bug in RHEL6 and clones /etc/cron.daily/0logwatch anacron script Date::Manip error

I saw the following error in root's mail on a server:

ERROR: Date::Manip unable to determine TimeZone.

Execute the following command in a shell prompt:
        perldoc Date::Manip
The section titled TIMEZONES describes valid TimeZones
and where they can be defined.

The error is due to the logwatch.pl script itself. The solution is to add the following line to /etc/cron.daily/0logwatch:

export DATE_MANIP=DM5
 
I found the solution here.
Why is Red Hat sending out an OS with a broken cron script?

With logwatch working, you then discover a missing gnome keyring library file.
You can find what package has that file using yum provides:

yum provides /lib64/security/pam_gnome_keyring.so

Install the following package to fix those PAM errors.

yum install gnome-keyring-pam-2.28.2-8.el6_3.x86_64









Saturday, August 10, 2013

Do Spies Really Know What They Are Doing, or Is It All Make-Believe?

Check out BUGGER . This blog post is about spies

The recent revelations by the whistleblower Edward Snowden were fascinating. But they - and all the reactions to them - had one enormous assumption at their heart. That the spies know what they are doing.
It's funny, and fascinating, and sad. It is also saying that we are wasting a lot of money chasing shadows and illusions dreamed up by people who have nothing else to do.

Journalists don't make out any better either.

Up to this point Pincher had been the Defence correspondent on the Daily Express. He was successful for getting "scoops" from "inside sources" - although the historian EP Thompson said that really Chapman Pincher was:

"A kind of official urinal in which ministers and intelligence and defence chiefs could stand patiently leaking."

One finds out why some people left that world.

But it was a world that was all made-up. Le Carre - who had himself been a spy - admitted this, and described what the true reality of the spy world was:

"For a while you wondered whether the fools were pretending to be fools as some kind of deception, or whether there was a real efficient service somewhere else.

Later in my fiction, I invented one.

But alas the reality was the mediocrity. Ex-colonial policemen mingling with failed academics, failed lawyers, failed missionaries and failed debutantes gave our canteen the amorphous quality of an Old School outing on the Orient express. Everyone seemed to smell of failure."

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